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      Order NO. C100318 CAS : [92921-24-9]
      英文名 Sulfo-SMCC
      別名 Sulfo-SMCC
      相關類別 蛋白異源雙功能交鏈試劑 儲存 冷凍(-20℃) 避光+干燥
      分子量 436.4 4-(N-馬來酰亞胺甲基)環己烷-1-羧酸磺酸基琥珀酰亞胺酯鈉鹽
      編 號 包裝 庫存 目錄價(¥) 您的價格(¥) 數 量
      C100318-0050 50 MG 現貨


      SMCC and its water-soluble analog Sulfo-SMCC are heterobifunctionalcrosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7~9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5~7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and loses its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2~7.5, with the NHS-ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryltargeted) reaction.


      Sulfo-SMCC is soluble in water and many other aqueous buffers to approximately 10 mM, although solubility decreases


      50 mg/bottle


      Molecular Weight 436.37
      Spacer arm 8.3
      Purity >98% on TLC
      Net Mass Added 219.09
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