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      Order NO. C100317 CAS : [64987-85-5]
      4-(N-馬來酰亞胺基甲基)環己烷-1-羧酸琥珀酰亞胺酯
      英文名 SMCC
      別名 SMCC
      相關類別 蛋白異源雙功能交鏈試劑 儲存 冷藏(2-8℃)
      分子量 334.3 4-(N-馬來酰亞胺基甲基)環己烷-1-羧酸琥珀酰亞胺酯
         
      編 號 包裝 庫存 目錄價(¥) 您的價格(¥) 數 量
      C100317-0050 50 MG 現貨
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      產品描述

      概述

      SMCC and its water-soluble analog Sulfo-SMCC are heterobifunctionalcrosslinkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7~9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5~7.5 to form stable thioether bonds. In aqueous solutions, NHS ester hydrolytic degradation is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and loses its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugations with these crosslinkers are usually performed at pH 7.2~7.5, with the NHS-ester (amine-targeted) reacted before or simultaneous with the maleimide (sulfhydryltargeted) reaction.

      應用

      SMCC is not directly water-soluble and must be dissolved in an organic solvent such as dimethylsulfoxide (DMSO) or dimethylformamide (DMF); subsequent dilution into aqueous reaction buffer is generally.possible, and most protein reactants will remain soluble if the final concentration of organic solvent is less than 10%.

      組份

      50 mg/bottle

      技術規格

      Molecular Weight 334.32
      Spacer arm 8.3
      Purity >98% on TLC
      Net Mass Added 219.09
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