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      Order NO. C100314
      3-馬來酰亞胺基苯甲酸琥珀酰亞胺酯(水溶性)
      英文名 Sulfo-MBS
      別名 3-Maleimidobenzoyl-N-hydroxysulfosuccinimide ester
      相關類別 蛋白異源雙功能交鏈試劑 儲存 冷凍(-20℃) 避光+干燥
      分子量 416.2 3-馬來酰亞胺基苯甲酸琥珀酰亞胺酯(水溶性)
         
      編 號 包裝 庫存 目錄價(¥) 您的價格(¥) 數 量
      C100314-0050 50 MG 現貨
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      產品描述

      概述

      MBS and its water-soluble analog Sulfo-MBS are heterobifunctional cross-linkers that contain N-hydroxysuccinimide (NHS) ester and maleimide groups that allow covalent conjugation of amine- and sulfhydryl-containing molecules. NHS esters react with primary amines at pH 7-9 to form amide bonds, while maleimides react with sulfhydryl groups at pH 6.5-7.5 to form stable thioether bonds. In aqueous solutions, hydrolytic degradation of the NHS ester is a competing reaction whose rate increases with pH. The maleimide group is more stable than the NHS-ester group but will slowly hydrolyze and also lose its reaction specificity for sulfhydryls at pH values > 7.5. For these reasons, conjugation experiments involving these cross-linkers are usually performed at pH 7.2-7.5, with the NHS-ester (amine-targeted) reaction being accomplished before or simultaneous with the maleimide (sulfhydryl-targeted) reaction.

      應用

      Sulfo-MBS is soluble in water and many other aqueous buffers to approximately 10 mM, although solubility decreases with increasing salt concentration

      組份

      50 mg/bottle

      技術規格

      Molecular Weight 416.3
      Spacer arm 7.3
      Purity >95% on TLC
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